Synthesis of Highly Substituted 2-Imidazolines through a Three-Component Coupling Reaction

Yao Han; Yong-Xin Xie; Lian-Biao Zhao; Ming-Jin Fan; Yong-Min Liang

doi:10.1055/s-2007-1000818

PAPER

Synthesis of Highly Substituted 2-Imidazolines through a Three-Component Coupling Reaction

Yao Han^a, Yong-Xin Xie^a, Lian-Biao Zhao^a, Ming-Jin Fan^b, Yong-Min Liang*^a,b
^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
^b State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: liangym@lzu.edu.cn;

Abstract

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Abstract

A simple strategy for the synthesis of highly substituted 2-imidazolines starting from terminal alkynes, sulfonyl azides, and N-unsubstituted aziridines via two steps with high regioselectivity is described.

Key words

2-imidazolines - sulfonyl azides - N-unsubstituted aziridines - three-component coupling - isomerization

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References

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The atomic coordinates for 2b have been deposited at the Cambridge Crystallographic Data Centre (deposition number CCDC 653812). The coordinates can be obtained on request from the Director Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; e-mail: deposit@ccdc.cam.ac.uk; fax: +44(1223)336033.

The atomic coordinates for 3a have been deposited at the Cambridge Crystallographic Data Centre (deposition number CCDC 653813). The coordinates can be obtained on request from the Director Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; e-mail: deposit@ccdc.cam.ac.uk; fax: +44(1223)336033.